Mr. K.O. Compared to the control, total protein in liver and kidney were statistically not altered except rats that were administered with 1200mg/kg JCEE that showed significant (p<0.05) decrease in the liver. Results obtained from the acute oral toxicity study revealed tolerance of experimental rat to acute administration of J. carnea ethanol extracts since no mortality and signs of toxicity were observed after 24h (Table1). However, the mechanism by which phytochemicals act as prooxidants in-vivo is still under investigation [25]. Google Scholar. In-vivo studies have revealed that radicals produced from these dietary antioxidants are constantly regenerated back to their active form by GSH in the ascorbate glutathione cycle. We currently have no information for JUSTICIA PECTORALIS overview. Generally disease free. Justicia carnea belongs to the family- Acanthaceae. 2007;112(1):13844. Mr. E.S. Check these Great Plant Combination Ideas with Justicia, Eye-Catching Retaining Walls and Staircases, An Eye-Catching Mediterranean Garden with Agave, Aloe and Pincushion, A Striking Water-Wise Border with Agave, Cactus and Ocotillo, A Beautiful Duo with Agave 'Blue Flame' and 'Blue Glow', A Long-Lasting Summer Garden Idea with Marigold and Sage, 8, 9, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, H1, H2. Fitoterapia. These antibodies help prevent infections and fight off diseases. 2015;15:236. https://doi.org/10.1186/s12906-015-0760-y. Adetuyi is a Professor of Biochemistry in the Department of Chemical Sciences, Faculty of Sciences, Olusegun Agagu University of Science and Technology, Okitipupa, Ondo State, Nigeria. One of the numerous nutritional benefits of justicia carnea leaves is in the possession of various forms of the B vitamins such as Vitamin B1, B2, B6, B9, and B12. [4].Inflammationinjuries, in an attempt to heal is presented by five cardinal signs of heat (calor), redness (rubor), swelling (tumor), pain (dolor) and loss of function5.Studieshave demonstrated inflammation as being caused by Keep an eye out for glasshouse red spider mite and glasshouse whitefly. Studies have shown that ewe eje isnt capable of causing damage to the liver. Kidney weight of rats treated with JCEE showed no significant difference with exception in 800mg/kg JCEE that demonstrated significant reduction. WBC reduced in rats treated with doses of J. carnea with significant decrease (p<0.05) in rats that received 50, 100 and 1200mg/kg body weight. https://doi.org/10.1186/s40816-020-00234-4, DOI: https://doi.org/10.1186/s40816-020-00234-4. Occupational Health and Safety in the Care and Use of Research Animals. The cuttings should be placed in individuals pots and put under glass or shaded location, away from direct sunlight. J Ethnopharmacol. It creates the perfect environment for aphids and dried sod. All authors read and approved the final draft of the manuscript. The species Justicia secunda Vahl belongs to the family - Acanthaceae - together with up to 600 other shrubs and herbs species. WebMD does not provide medical advice, diagnosis or treatment. Acute toxicity was determined in two phases using Lorke method. Extraction was carried out by maceration (72h) following the method of Onoagbe et al., [13]. In the study conducted by Onyeabor and his colleagues, it was shown that the leaf extract not only reverses anemic condition, but also lowered the lipid profile of the experimental rats. Safety assessment of oral administration of ethanol extract of, $$ \mathrm{Total}\ \mathrm{protein}\kern0.5em =\kern0.5em \frac{\mathrm{Absorbance}\ \mathrm{of}\ \mathrm{sample}}{\mathrm{Absorbance}\ \mathrm{of}\ \mathrm{standard}}\kern0.5em \times \kern0.5em \mathrm{Concentration}\ \mathrm{of}\ \mathrm{standard} $$, $$ \mathrm{Catalase}\ \mathrm{activity}\ \left(\mathrm{U}/\mathrm{ml}\right)=\kern0.5em \frac{\Delta \mathrm{A}/\min \kern0.5em \times \kern0.5em \mathrm{TV}}{\upvarepsilon \kern0.5em \times \kern0.5em \mathrm{SV}\kern0.5em \times \kern0.5em \mathrm{TP}} $$, $$ \mathrm{SOD}\ \mathrm{activity}\ \left(\mathrm{U}/\mathrm{ml}/\mathrm{mg}\ \mathrm{protein}\right)\kern0.5em =\kern0.5em \frac{\Delta \mathrm{A}/\min \kern0.5em \times \kern0.5em \mathrm{TV}}{\upvarepsilon \kern0.5em \times \kern0.5em \mathrm{SV}\kern0.5em \times \kern0.5em \mathrm{TP}} $$, $$ \mathrm{Concentration}\kern0.5em \mathrm{of}\kern0.5em \mathrm{reduced}\kern0.5em \mathrm{GSH}\kern0.5em =\kern0.5em \frac{\left(\Delta \mathrm{A}\kern0.5em \times \kern0.5em \mathrm{TV}\right)}{\left(\upvarepsilon \kern0.5em \times \kern0.5em \mathrm{SV}\kern0.5em \times \kern0.5em \mathrm{TP}\right)} $$, $$ \mathrm{Malondialdehyde}\kern0.5em =\kern0.5em \frac{\left(\mathrm{A}\kern0.5em \times \kern0.5em \mathrm{TV}\right)}{\Big(\upvarepsilon \kern0.5em \times \kern0.5em \mathrm{SV}\kern0.5em \times \kern0.5em \mathrm{TP}} $$, https://doi.org/10.1186/s40816-020-00234-4, https://doi.org/10.1016/j.jep.2015.06.005, https://doi.org/10.1016/j.joad.2015.08.006, https://doi.org/10.1016/j.jep.2005.06.013, https://doi.org/10.3109/08860220903367585, https://doi.org/10.1590/S0102-695X2011005000196, https://academicjournals.org/journal/AJPS/article-full-text-pdf/6AA410310867, https://doi.org/10.35841/biomedicalresearch.30-18-666, https://doi.org/10.1016/j.jep.2007.02.011, https://doi.org/10.1186/s40816-019-0104-4, https://doi.org/10.1016/j.fitote.2008.02.005, https://doi.org/10.1016/j.jada.2008.06.430, https://doi.org/10.1016/j.biocel.2006.07.001, https://doi.org/10.1186/s12906-015-0760-y, http://creativecommons.org/licenses/by/4.0/. Feed the soil when the cutting is new to encourage better growth. However, scientifically it is called Justicia carnea. Pinch out tips to promote compact plants. 8-10 Justicia carnea leaves. Onoagbe IO, Attah V, Luther MM, Esekheigbe A. Hypoglycemic and anti-diabetic effects of Morinda lucida and Tetracera alnifora in normal and streptozotocin-induced diabetic rats. 2008;79:3326 https://doi.org/10.1016/j.fitote.2008.02.005. Consumption of medicinal plants has diverse therapeutic benefits and could also have toxic effect. 2005 - 2023 WebMD LLC, an Internet Brands company. Oral acute toxicity study on J. carnea ethanol extract (JCEE) was carried out according to Lorke [15] method using the total of twelve (12) albino rats in two phases. The roots and the leaves possess medicinal values and have been used in treating several diseases. They look terrific in properly shaded outside areas such as porches, patios, driveways, and entryways. Therapeutic Research Faculty 2020. if you add justicia carnea leaves in avocado seed tea, you may just get yourself the best remedy for cardiovascular diseases. Lorke D. A new approach to practical acute toxicity testing. Justicia carnea (belonging to Acanthaceae family) is a flowering plant consisting ~600 species that are widely distributed in the tropics and subtropics [7]. During the growing season, the justicia (plant) should be watered thoroughly with room temperature water. Sci. Exactly 1.0ml of tissues (liver and kidney) was deproteinised using 0.1ml of 10% TCA and centrifuged at 650g for 5min to obtain supernatant. The hematopoietic systems represent a sensitive target of toxic compounds and an essential index of physiological and pathological status in experimental animals [24]. Justicia carnea is a medicinal plant used widely in Nigeria which is reported to have diverse functions, including blood-boosting potential. Google Scholar. The absorbance of the supernatant was measured against reagent blank at 532nm. Beijing: Chemical Press; 2011. It is nicknamed the Blood leaf, Blood of Jesus, and Jehovah Witness leaf in Nigeria, and is a widely used leaf across states in Nigeria. Justicia carnea (Brazilian Plume) is an upright, evergreen shrub with large, dark green leaves, 10 in. Be careful about the moisture in the soil, avoiding letting it dry completely. 2010;32(1):1328 https://doi.org/10.3109/08860220903367585. At the end of the 14th day of administration, the rats were allowed to fast overnight and sacrificed the following morning by anesthetizing each rat in a closed chamber containing drops of chloroform. The mixture was incubated at 28C for 30min and the absorbance read at 550nm against the reagent blank. What this means is that aside fighting anemia, justicia carnea leaves also improves your cardiovascular health by suppressing the tendency for dyslipidemia. Chidubem Olovo is a biochemist and a researcher whose interest is centered on the chemistry of natural products, their pharmacological properties and how using the plant sources can improve human healthy living. The ameliorative effect of Justicia carnea on blood glucose level and lipid profile in alloxan-induced diabetic albino rats was evaluated in a study titled, "Effects of methanol leaves extract . We use cookies on this website, you can read about them here. View abstract. Effect of Tectona grandis on phenylhydrazine induced anemia in rats. The cuttings are taken from the parent plant in the spring after the plant has bloomed. By using this website, you agree to our Washington, DC: The National Academies Press; 1997. https://doi.org/10.17226/4988. Too much sun can scorch the leaves, and too little will result in fewer flowers. Ewe eje can increase blood count and volume. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version. It is commonly referred to as blood root, blood booster, ewe eje in Yoruba, Ogwu obara in Igbo, and jacobinia in Brazil and south America. As a consequence, depletion of reduced glutathione (GSH) either by removal from the cell or oxidation to GSSG could eventually lead to mild oxidative stress in cells and tissues [33, 34]. PubMed Central The results of this study suggests that ethanol extract of J. carnea leaf is relatively safe, could be beneficial in alleviating hematology related abnormalities without causing adverse effects on endogenous antioxidant system. The appropriate dose of Justicia pectoralis depends on several factors such as the user's age, health, and several other conditions. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. 1958;25(1):192205. While not necessary, prune the justicia (plant) freely to maintain the desired shape and size. Medapa S, Singh GRJ, Ravikumar V. The phytochemical and antioxidant screening of Justicia wynaadensis. 2). The plant looks great along garden borders and near building foundations. While every effort has been made to describe these plants accurately, please keep in mind that height, bloom time, and color may differ in various climates. It has already been pointed out that this plant is used traditionally to boost blood production among the people of southern Nigeria. However, watch out for nematodes and spider mites. 1. The animals were allowed free access to rat chow and water ad libitum. Ashwagandha tea: 10 benefits, side effects and recipes, 7 interesting health facts about Black sapote fruits. Justicia carnea, the Brazilian plume flower, Brazilian-plume, flamingo flower, or jacobinia, is a flowering plant in the family Acanthaceae. Acute and sub-acute toxicity studies of aqueous and methanol extracts of Nelsonia campestris in rats. The red coloration of the decoction made people think that the plant must contain blood boosting compounds. In winter, you might have to spray the leaves with water, especially if the air is dry. Extinction coefficient () of MDA TBA complex=1.56105M1cm1. Microsomal lipid peroxidation. 3rd ed. 400). Venancio, E. T., Rocha, N. F., Rios, E. R., Feitosa, M. L., Linhares, M. I., Melo, F. H., Matias, M. S., Fonseca, F. N., Sousa, F. C., Leal, L. K., and Fonteles, M. M. Anxiolytic-like effects of standardized extract of Justicia pectoralis (SEJP) in mice: Involvement of GABA/benzodiazepine in receptor. Higher doses (>500mg/kg) of extract significantly (p<0.05) increased RBC, hemoglobin and platelet compared to the control. Google Scholar. Ani, Onuabuchi & Udedi, Stanley & Asogwa, Kingsley & Enemali, Michael & Onwelumadu, Chigozie & Ikedife, Kenneth. Assessment of Aloe vera (L) genotoxic potential on Escherichia coli and plasmid DNA. Liver superoxide dismutase (SOD) activity was significantly (p<0.05) increased at 1200mg/kg while other tested doses caused no detrimental effect on glutathione, catalase, SOD and malondialdehyde level in liver and kidney. We'll respect your privacy and unsubscribe at any time. After 72h of soaking, the wine (dark purplish red) colored filtrate was filtered using a double cheese cloth, concentrated under reduced pressure using rotary evaporator and subsequently water bath at 40C to obtain a slurry (dark purple) extract termed Justicia carnea ethanol extract (JCEE). BMC Complem Altern Med. Blooming from early summer to fall, the flowers are attractive to hummingbirds and butterflies. Justicia carnea needs bright, indirect light to thrive. In a study conducted by Onyeabor and colleagues, the leaf extract of jusiticia carnea reverses the anemic effect of phenylhydrazine on the pack cell volume, red blood cell, and hemoglobin concentrations. They are also needed in strong bone formation, and in cellular and neuronal functions. The liver and kidneys were excised and rinsed immediately in a normal saline (0.9% Nacl) to remove blood stain, dried between layers of Whatman filter paper, weighed and homogenized to obtain the supernatant for biochemical analysis. National Research Council. Based on estimation by World Health Organization (WHO), larger percentage (between 80 and 90%) of the worlds population especially in developing countries depends on traditional system of medicine [1, 2]. Badami S, Aneesh R, Sankar S, Sathishkumar MN, Suresh B, Rajan S. Antifertility activity of Derris brevipes variety coriacea. To use the website as intended please Methods. It is believed by local consumers in Ghana to possess anti-anaemic effects that boost blood levels in pregnant women, anaemic patients and also . Background: Justicia carnea is a medicinal plant used widely in Nigeria which is reported to have diverse functions, including blood-boosting potential. Organic extract of Justicia pectoralis Jacq. Eyong EU, Umoh IB, Ebong PE, Eteng MU, Antai AB, Akpa AO. Antioxidants & redox signaling Forum Review. This may be because of its hepatoprotective activity. 1978;90:819. Aim. Tags: benefits of justicia carnea, health benefit of justicia carnea, justicia carnea . Google Scholar. However, further research needs to done to determine the mode of action of the plant, and it's effects on humans. Note this is the default cart. You can add the leaves and water altogether in a pot and allow to boil till the water turns red. This study has confirmed the safety of ethanol extract of J. carnea leaf and validates its conventional use as blood booster. It also grows in some Caribbean islands, including Trinidad and Tobago. Different researches performed on wistar rats has proven the non toxicity of justicia carnea. Why urban citizens in developing countries use traditional medicines: the case of suriname. 400). The plant, which is usually green in color and produces pink flowers, belongs to the family of Acanthaceae. CAS Afr J Tradit Complement Altern Med. Clin Phytosci 2019; 5:9. https://doi.org/10.1186/s40816-019-0104-4. Summarily, experimental group shows some degenerative changes that can be termed as necrosis, some mild fibrosis and hemorrhage characterized by the presences of infiltrated red hemorrhagic and inflammatory cells. Ewe eje or ewe ajeri is prepared differently by different folks. Justicia carnea is a popular ornamental plant, which possesses powerful medicinal values. Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Group 2, 3, 4, 5, 6 were respectively administered orally with 50, 100, 500, 800 and 1200mg/kg body weight of JCEE once daily for 14days using an oral gavage. SOD activity was determined by its ability to inhibit the auto-oxidation of epinephrine determined by the increase in absorbance at 480nm. While the renal tubules across the tested groups were normal with the interstitial spaces showing moderate congestion and hemorrhage, there appeared some abnormalities in the renal cortex (such as few sclerotic glomeruli with moderately dilated capsular spaces) resulting in fair architectural structure of the kidney (Fig. There is however little publications available on the pharmacological properties of the herbal plant. Star Apple: Amazing Health Benefits of eating its fruits. How to make Ewe eje Extracthow to prepare justicia carnea. The minerals present in justicia carnea (Ewe eje or ogwu obara) are calcium, iron, magnesium, copper and zinc. Ewe eje is good for the liver. Justicia Carnea is a flowering plant that may be found in our neighborhood. This is attributed to the anti-hyperlipidaemic properties of the plant. Superoxide dismutase was carried out using the method of Sun and Zigma [18]. Photomicrograph of a liver sections stained with Haematoxylin and Eosin (Mag. Justicia carnea is a medicinal plant that is used conventionally as blood tonic from time immemorial in Nigeria. Water your plants deeply during growth periods, allowing the soil to dry . Proximate analysis of the aqueous extract of J. carnea leaves showed that it contains appreciable amounts of 53.07 0.07% carbohydrate, 9.26 0.02% ash, and 26.71 0.02% . Google Scholar. Also observed is a distortion in the walls of the blood vessels (red arrow), pyknotic hepatocytes and signs of inflammation (red arrow), Photomicrographs of kidney sections stained with Haematoxylin and Eosin (Mag. As declared by all authors, no competing interests exist. Ogbe RJ, Adoga GI, Abu AH. Authors TSO, KOK and ESA manage experimental protocols and performed the experiments under the supervision of FOA. It can be used to manage diabetes consition properly. They can easily tolerate acidic to slightly alkaline sandy, loamy, and clay soils. There are several claims that justicia carnea can prevent epilepsy and convulsion among children. Leal, L. K., Ferreira, A. Acta Sci Pol Technol Aliment. The animals were initially examined for any signs of toxicity after 60min of administration and further observed for a period of 24h. The absence of rat mortality in phase I necessitated the conduct of the second phase.